
Otherwise known under the name of Tretinoin, Avita, and Renova, Retin-A is a form of the popular vitamin A used to increase cell turnover and therefore acne and possibly even scars. However, it should be noted that dead skin cells can still build up on the skin, requiring exfoliation. It also does not in and of itself shrink pores or allow oxygen into the pores in order to kill the bacteria. Nor does it provide any other way of killing the bacteria. However, like benzoyl peroxide, whether used from the inside or out, Retin-A can cause serious side effects as well as irritation upon application to the skin. Many experience flaking, which can be disconcerting and ugly to say the least. Some have used it for several weeks, and it has had an extremely slow effect, leading to the thought that it didn’t work for them. This can be true in some instances. But Retin-A works as a gradual pace and is actually proven to produce results. So patience is needed with this particular item. It can take 6-9 weeks to see results at all, and it has to be used for at least a year. For all these reasons, Retin A can be an undesirable alternative.

One of the most popular acne treatments to ever hit the market, Proactiv is a worldwide product marketed by the idea that it was developed by 2 dermatologists. Others using their main ingredient, benzyl peroxide have been developed before and since, but none have quite measured up to its marketing, not even those Proactiv imitators such as Acne Free. But despite their main claim of treating acne, Proactiv also claims to reduce acne by getting rid of blackheads and shrinking pores, largely with their toner.
As one might find, there are many ways and many combinations of ways to kill blackheads. First one might say that you want to get rid of the dead skin cells by exfoliating. The Proactiv scrub has this. Second, you might say that you should allow oxygen into the pores to kill bacteria, there is no verification that Proactiv does this, and it may well be the most important part. Finally, you want to shrink the pores so that more bacteria cannot get in. Proactiv supposedly does this, but does not actually use astringents such as witch hazel that would do that.
Active Ingredient: benzoyl peroxide 2.5%.
Inactive Ingredients: water (aqua), magnesium aluminum silicate, glyceryl stearate, PEG-100 stearate, disodium dimethicone copolyol sulfosuccinate, sorbitol, dimethyl isosorbide, polyethylene, tridecyl stearate, neopentyl glycol dicaprylate/dicaprate, tridecyl trimellitate, cetyl esters, anthemis nobilis flower extract, sodium hyaluronate, sodium PCA, propylene glycol, xanthan gum, imidazolidinyl urea, methylparaben, propylparaben, fragrance (parfum).
Ingredients: water (aqua), glycolic acid, hamamelis virginiana (witch hazel) extract, anthemis nobilis flower extract, rosa canina fruit extract, aloe barbadensis leaf juice, sodium PCA, panthenol, glycerin, propylene glycol, allantoin, polysorbate-20, hydroxyethylcellulose, sodium hydroxide, benzophenone-4, tetrasodium EDTA, methylparaben, propylparaben, imidazolidinyl urea, fragrance (parfum), blue 1, yellow 5.
Active Ingredient: benzoyl peroxide 2.5%.
Inactive Ingredients: water (aqua), cyclomethicone, ethoxydiglycol, propylene glycol, glyceryl stearate, PEG-100 stearate, cetearyl alcohol, dimethicone, panthenol, allantoin, carbomer, ceteareth-20, xanthan gum, triethanolamine, diazolidinyl urea, methylparaben, propylparaben, fragrance (parfum).
According to the official Proactiv website, side effects include only dryness, which can apparently be remedied by using their moisturizer included in the basic pack. But in truth, even customers who have used the whole combination often report dryness, redness, increased sun sensitivity, increased acne, allergic reactions, etc, again even when using the Proactiv moisturizer.
In analysis of the Proactiv formula, it lacks many of the essential ingredients required to effectively treat blackheads. It also has quite a few side effects that naturally the Proactiv manufacturers will not name. There are literally hundreds of acne treatments, both over the counter and prescription that use benzyl peroxide in different concentrations. But if you are looking for something different, we suggest Oxycerin, which has tea tree oil, a gentler formula with the same positive effects as benzyl peroxide.
Pore Strips Review Pore strips are a classification of blackheads treatments. They are not targeted at all toward acne, but specifically blackheads. They come from companies such as Biore and Clean and Clear. But they can be extremely expensive for some. The best effects can come from heating the nose with a hot washcloth before application. But application takes some time, especially considering it has to dry. Products like Biore use ingredients such as titanium dioxide and butylene glycol, which can damage the skin easily, but they do not actually use acne fighting or pore decreasing ingredients. The biggest problem with these items is that first, you do have to heat the nose before to loosen the bacteria, or it can be extremely ineffective at best. And second, pore strips often leave gaping and open holes, inviting bacteria to again gather quickly into the pores and cause more blackheads. They may seem cheap if you don’t consider how many you will have to use every month. But pore strips are not worth it at this time.

Largely a grocery store brand, Neutrogena has produced what they call the “complete acne therapy treatment system.” It combines a skin polishing acne cleanser, an acne control lotion, and an oil free SPF 15 lotion to target acne at one of the major sources, blackheads. They promise it will work because it supposedly reduces blackheads, whiteheads, inflammation, oiliness, bacteria, improves skin texture, reduces bumps, and visibly reduces the appearance of acne all in 4 days. They even claim that in a clinical trial 81% of subjects agreed it didn’t dry their skin, but did they agree that it worked is the question.
In order to kill bacteria, there are various ways to deal with blackheads and often several steps to achieve this. First, you have to get rid of the dead skin cells that may be clogging the pores, generally by exfoliating. We see no indication that this would happen with Neutrogena. Second, it would have to allow oxygen into the pores, which would kill bacteria in and of itself. Again, we see nothing to verify this with Neutrogena. Finally, you would want to shrink pores to protect from future blackheads, again we see no verification of this.
Active ingredients: Salicylic acid
Inactive Ingredients: Water, Sodium Methyl Cocoyl Taurate, Cocamidopropyl Betaine, Sodium Cocoamphoacetate, Glycol Distearate, Polyethylene, Glycolic Acid, Sodium Lactate Cocamidopropyl PG-Dimonium Chloride Phosphate, Polyquaternium-11, Disodium EDTA, Fragrance.
Active Ingredients: Benzoyl Peroxide 2.5%
Inactive Ingredients: Water, Carbomer, Sodium Hydroxide, Laureth-4, Hydroxypropyl Methylcellulose, Disodium EDTA.
Active Ingredients: Octinoxate 7.5%, Zinc Oxide 2.94%
Inactive Ingredients: Water, Glycerin, Pentylene Glycol, Cetearyl Alcohol, Portulaca Oleracea Extract, Butylene Glycol, Capryloyl Glycine, Dicetyl Phosphate, Glyceryl Stearate, PEG-100 Stearate, Caprylyl Methicone, Sarcosine, Cinnamomum Zeylanicum Bark Extract, Hexylene Glycol, Cedrus Atlantica Bark Extract, Propylene Glycol, Triethoxycaprylylsilane, Ceteth-10 Phosphate, Methylparaben, Propylparaben, Ethylparaben, Isopropylparaben, Isobutylparaben, Butylparaben, Disodium EDTA, Xanthan Gum Fragrance.
According to Neutrogena, there are no side effects. But with Benzoyl Peroxide in the mix, many users tend to report dryness, redness, irritation, peeling, increased sun sensitivity, which would explain the need for a specialized sunscreen(though only 15 SPF), etc. In addition, though advertised as sunscreens, oxinoxate and zinc oxide are actually industrial chemicals that can easily irritate your skin, even more than benzoyl peroxide. There are various other ingredients that can easily cause side effects.
Without question, there are quite a few side effects that the Neutrogena website does not disclose. They do have some proven ingredients, but we are curious to see what study they are citing, probably one conducted with serious bias by their own team of paid researchers, because we have not actually been able to find any published study with those results. If you are looking for a simpler, easier, and less damaging solution, all our top products are one step programs with new and innovative acne ingredients.

Popularly known as Accutane, Isotretinoin is a prescription only treatment specially used for only extremely severe cases of acne and even resistant forms outside the realm of acne vulgaris. It shrinks pores, which can actually cause a more severe acne breakout initially and trap bacteria beneath the surface in an undesirable way. It should be noted that those who are pregnant, nursing, or even have a possibility of becoming pregnant should not take Isotretinoin due to the risk of severe birth defects. However, more common side effects include dry or fragile skin, pinkeye, dry or cracked lips, dry mouth, dry nose, itching, joint pains, and nosebleeds. Others include bowel inflammation and pain, chest pain, decreased night vision, decreased tolerance to contact lenses, delay in wound healing, depression, fatigue, headache, nausea, peeling palms or soles, rash, skin infections, stomach and intestinal discomfort, sunburn-sensitive skin, thinning hair, urinary discomfort, vision problems, vomiting. Accutane can be extremely effective in long term blackhead prevention. But the immediate treatment is less likely, and it should only be used as a last choice for extreme cases such as acne conglata and resistant forms of acne vulgaris.

Promoted as a blackhead treatment, Differin gel is meant to clear acne and then prevent it from happening again. It uses 0.1% or 0.3% of their active ingredient, depending on which formulation you choose. It is supposed to be easier to tolerate for some patients, and it is largely sold through doctors. They even offer a free trial offer through the Differin website. It contains an ingredient known as adaptalene, and it is generally used as a treatment for acne vuglaris. However, ingredients like benzoyl peroxide require around 5%, and so logic would follow that adaptalene has some of the same standards.
According to sources, adaptalene works by increasing skin cell turnover. So in the long run, it may eventually reduce acne. But it does not specifically target blackheads. It does not necessarily decrease dead skin cells resting on the surface, it does not clear pores of bacteria, and it does not actually shrink the pores over time.
Active Ingredients: Adaptalene
Inactive Ingredients: carbomer 940, edetate disodium, methylparaben, poloxamer 124, propylene glycol, purified water, and sodium hydroxide
Possible side effects of Differin include dryness, itchiness, redness, burning, and peeling. They also note that your acne could actually get worse in the first few days. In addition, erythema or pruritus could occur with Differin gel. Animal studies have also shown birth defects in connection with Differin. You should not use Differin if you suffer from allergies, are over the age of 65, are pregnant, and are taking certain medications or eating certain types of food such as alcohol or tobacco. If you suffer from eczema or seborrheic dermatitis, you should also refrain from using this product. It should also not be combined with other acne treatments due to increased risk of skin irritation.
Differin is a prescription acne treatment for a reason. It comes with some relatively severe and studied side effects, and unlike benzoyl peroxide, it is only used in extremely small concentrations, and cannot be found anywhere on the over the counter market. It can actually increase acne problems, and it has not been shown to have real effect against blackheads. We would not suggest Differin for all these reasons, especially if you would like to get rid of blackheads.

A specialized blackhead treatment, DERMAdoctor Aint Misbehavin claims to target blackheads at their source to provide quick and lasting results. It is baed on 2% salicylic acid as well as retinol and glycolic acid to supposedly accomplish this goal. In 3 steps, it cleans, tightens, and prevents the skin from developing more blackheads. DERMAdoctor has a range of other products, all specializing in one and only one area. And of course, the official website claims that the average rating is 5 stars. That must mean that all the reviews are 5 stars, and they cite a few that are somewhat indescript.
Killing blackheads requires 3 steps: exfoliating, flushing out bacteria, and shrinking the pores. Despite what they would have you think, salicylic acid does not do any of these things. It does have antioxidants, which may kill free radicals. But they do not actually attack certain types of bacteria. In addition, retinol, while it can irritate the skin, also does not disinfect or exfoliate. It has quite a few moisturizers and preservatives, but no ingredients that would exfoliate, flush out bacteria, or shrink the pores. They do name these elements specifically in their description, but don’t follow through.
Active Ingredient: Salicylic Acid 2%
Inactive Ingredients: Aqua (Water), SD-40B Alcohol, Glycolic Acid, Sodium Glycolate, Azelaic Acid, Saccharum Officinalis (Sugar Cane) Extract, Citrus Medica Limonum (Lemon) Extract, Citrus Aurantium Dulcis (Orange) Extract, Pyrus Malus (Apple) Extract, Camellia Sinensis (White Tea) Leaf Extract, Salix Nigra (Willow) Bark Extract, Polyacrylamide, C13-C14 Isoparaffin, Laureth-7, Aluminum Zirconium Tetrachlorohydrex Gly, Cyclomethicone, Glycerin, Retinol, Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer, Hydroxyethylcellulose, Xanthan Gum, Phenoxyethanol, Butylparaben, Ethylparaben, Methylparaben, Propylparaben
With all the included ingredients, DERMAdoctor Aint Misbehavin is meant only for external use and those with hardy skin. Otherwise, it may cause allergic reactions, increase sensitivity to the sun, redness, warming of the skin, toxicity, soft spot on the head, headaches, dizziness, fatigue, malaise, blurry vision, bone pain, swelling, nausea, vomiting, peeling, irritation, etc.
Dermadoctor Aint Misbehavin has named the right elements in their description, but not in their ingredients list. They have many potential irritants and some that though irritating may make a difference in some cases of acne. However, they are not targeted to treat blackheads in any way. We would not recommend it in most cases, but especially not for such a targeted idea.

Promising blemish free, spot free, and blackhead free skin, Clearpores claims to be the single treatment that will finally work for even those who have suffered through acne their whole lives. They use a 3 part system that they claim is unique, but is actually similar to Proactiv, to “fight the acne bacteria from the inside and out.” It features “doctors and herbalists” to promote their product, and they also cite the “medical community.” Above all, they promise clear skin, shine free skin, no more white/black heads, and reduction in redness, swelling, and scarring.
As you may have noticed, we have a 3 step program to get rid of ugly blackheads. First you exfoliate, The only active ingredients in all these products are salicylic acid and SD alcohol. Neither of these are exfoliants. And none of the inactive ingredients in the mix are either. Second, you allow oxygen into the pores to kill bacteria, again no ingredients that would achieve this process. Finally, you want to use an astringent such as witch hazel, they do not provide this.
Dandelion root, aloe vera, yellow dock, echinacea purpurea, red clover, sasparilla root,burdock root, licorice root, tumeric, atlantic kelp, cayenne, duratex, and magnesium stearate
Active Ingredient: SD Alcohol 40 (1%), Salicylic Acid (2%)
Other Ingredients: Deionized Water, Disodium, Laurethsulfosuccinate, Aloe Barbadensis Leaf Juice, Cocamidopropyl Betaine, PEG-150 Pentaerythrityl Testrastearate, Lauramide Diethanolamide, Glycerine, Ethoxydiglycol, Sodium Acrylate/Sodium Acryloyldimethyl Taurate, Ishohexadecane. Polysorbate 80, Salicyclic Acid, Olive Leaf Extract,Peg – 7 Olive Oil Esters, Sodium Hydroxymethylglycinate, Tocopheryl Acetate, Hydrolyzed Wheat Protein, Potassium Sorbate.
Active Ingredient: Salicylic Acid (2%), SD Alcohol 40 (1%)
Other Ingredients: Water (Aqua), Cyclopentasiloxane, Glycerin, Butylene Glycol, Dimethicone, Cetearyl Alcohol, Cyclohexasiloxane, Panthenol, Capryloyl Glycine, Hydrolyzed Linseed Extract, Spiraea Ulmaria Extract, Bisabolol, Retinol, Phospholipids, Tocopheryl Acetate, Ascorbyl Palmitate, Retinyl Palmitate, Dipotassium Glycyrrhizate, Farnesol, Polysorbate 60, Glyceryl Stearate, PEG-100 Stearate, Calcium Aluminum Borosilicate, Pentylene Glycol, Polysorbate 20, Sclerotium Gum, Xanthan Gum, Sodium Hydroxide, Disodium EDTA, Phenoxyethanol, Methylparaben, Propylparaben.
Active Ingredient: Salicylic Acid (2%), Salicylic Acid
Other Ingredients: Cetostearyl Alcohol, Dimethicone, Disodium EDTA, Glyceryl Stearate (and) PEG-100 Stearate, Glycolic Acid, Isopropyl Palmitate, Lipoic Acid, Magnesium Aluminum Silicate, Methylparaben, Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, Propylene Glycol, Propylparaben, Sodium Hydroxide, Steareth-2, Steareth-21, Water, Xanthan Gum.
Active Ingredient: Salicylic Acid (1.5%)
Other Ingredients: Water, Cetearyl Alcohol, Ceteareth-20, Isopropyl Palmitate, Glycerin, Butylene Glycol, Sodium Carboxymethyl Betaglucan, Lactic Acid, Cyclomethicone, Dimethyl MEA (DMAE), Polysilicone-11, Glycine Soja (Soybean) Seed Extract, Ceramide 3, Propylene Glycol, Dimethicone, Petrolatum, Camellia Oleifera (Green Tea) Extract, Diazolidinyl Urea, Allantoin, Bisabolol, Methylparaben, Propylparaben, Disodium EDTA, Sodium Hyaluronate.
Clearpores uses two different kits for the body and face. But all of them include harmful chemicals such as parabens, SD alcohol, and others that will dry out and damage your skin, much in the way benzoyl peroxide would. So expect more damage to your skin than the benefits you will actually reap.
Clearpores is endorsed by doctors just as every other product containing the proven salicylic acid would be. However, in and of itself, it is not endorsed by physicians above any other formula based on salicylic acid or benzoyl peroxide. It has some harmful chemicals, and few results when it comes to blackheads. And considering the relatively low concentrations of salicylic acid, we have to highly doubt that a physician looking over it would actually suggest it.

“Teach your blackheads a lesson.” Clean and Clear Advantage says that skincare is not just cleansing alone, which is true. Cleansing alone, even with the right exfoliator, will not actually address all the main causes of acne and blackheads, at least not in the case of most scrubs. As such, the best solution for blackheads out of the name and description alone would probably be the deep action cream cleanser. But they propose the Clean and Clear Advantage Kit to be the best solution, probably because it makes them more money. It includes a Clean and Clear Advantage cleanser, oil free acne moisturizer, acne clearing astringent, and spot treatment.
To target blackheads, there are 3 key steps. First you must exfoliate away dead skin cells, because they are one of the major elements blocking pores and building up on the skin. There are actually no exfoliators in Clean and Clear Advantage. The second step would be to allow oxygen into the pores, again no ingredients that would do this. And finally, you would want to shrink the pores. Generally speaking, the astringent would be the one to do this. But all of their products are based on benzoyl peroxide and salicylic acid, even the astringent. It has no ingredients, active or inactive, that would actually shrink the pores such as witch hazel would.
Active Ingredients: Benzoyl Peroxide, Salicylic Acid
Inactive Ingredients: Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-15 Alkyl Benzoate, Carbomer, Fragrance, Glycerin, Menthol, Mineral Oil, Petrolatum, Potassium Polyphosphate, Sodium C14-16 Olefin Sulfonate, Sodium Cocoyl Isethione, Titanium Dioxide, Water, Zinc Lactate
Active Ingredients: Salicylic Acid 0.5% (Acne medication)
Inactive Ingredients: Benzalkonium Chloride, Butylene Glycol, C12-15 Alkyl Benzoate, C12-15 Alkyl Lactate, C13-14 Isoparaffin, Capryloyl Glycine, Cedrus Atlantica Bark Extract, Cetearyl Alcohol, Cetearyl Glucoside, Cetyl Lactate, Cinnamomum Zeylanicum Bark Extract, Cocamidopropyl PG-Dimonium Chloride Phosphate, Dimethicone, Disodium EDTA, Ethylene/Acrylic Acid Copolymer, Fragrance, Glycerin, Glycine Soja (Soybean) Seed Extract, Isoceteth-20, Laureth-7, Methyl Gluceth 20, PPG-10 Cetyl Ether, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Phenoxyethanol, Phenyl Trimethicone, Polyacrylamide, Polysorbate 60, Portulaca Oleracea Extract, Propylene Glycol, Sarcosine, Steareth-21, Water
Active Ingredients: Salicylic Acid 1% (Acne Medication)
Inactive Ingredients: Alcohol (38%), Benzalkonium Chloride, Butylene Glycol, C12-15 Alkyl Lactate, Capryloyl Glycine, Cedrus Atlantica Bark Extract, Cetyl Lactate, Cinnamomum Zeylanicum Bark Extract, Cocamidopropyl PG-Dimonium Chloride Phosphate, Denatonium Benzoate, Dimethicone Propyl PG-Betaine, Fragrance, Isoceteth-20, PEG-32, PPG-5-Ceteth-20
Active Ingredients: Salicylic Acid 2% (Acne Medication)
Inactive Ingredients: Alcohol (14%), Ammonium Hydroxide, Benzalkonium Chloride, Butylene Glycol, C12-15 Alkyl Lactate, C13-14 Isoparaffin, Capryloyl Glycine, Cedrus Atlantica Bark Extract, Cetyl Lactate, Cinnamomum Zeylanicum Bark Extract, Cocamidopropyl PG-Dimonium Chloride Phosphate, Cyclopentasiloxane, Dehydroxanthan Gum, Fragrance, Glycerin, Hamamelis Virginiana (Witch Hazel) Extract, Laureth-7, PPG-2 Isoceteth-20 Acetate, Phenethyl Dimethicone , Phenoxyethanol, Polyacrylamide, Polysorbate 20, Portulaca Oleracea Extract, Propylene Glycol, SD Alcohol 40-B, Sarcosine, Tetrasodium EDTA, Water
With most of the products active ingredients, there will be no side effects, however with benzoyl peroxide there will be such as redness, itchiness, dryness, sun sensitivity, etc. But with no components to protect from the sun or truly moisturize, there’s no protection element. It also uses industrial chemicals such as titanium dioxide that will seriously damage the skin as preservatives.
Clean and Clear Advantage focuses on quite a few cheap ingredients and produces formulas that are basically the same formula over and over with slight variations. They don’t actually provide ingredients that would adhere to the names, nor ingredients that would clear blackheads in any way, shape, or form. Tea tree oil on the other hand as well as ingredients found in our other top products would.

Out of the entire Biore line, the warming anti-blackhead cream cleanser is supposed to the main one meant to target blackheads and make them virtually disappear. They even claim it “cleans five times better than any other warming cleanser while leaving the skin fresh and smooth.” This is very specific considering there are only a few warming cleansers, while there are quite a few different blackhead treatments in general.
Killing blackheads takes 3 steps. First you have to exfoliate. The only active ingredient in Biore warming anti blackhead cream cleanser is salicylic acid, which does not exfoliate, nor did we see an ingredient in the inactive ingredients that would exfoliate. Second, you have to allow oxygen to infiltrate the pores, which again, the warming anti blackhead cream cleanser does nothing to promote. And finally shrinking pores, the warming anti blackhead cream cleanser definitely does not do this.
Active ingredient: Salicylic acid 2.0%
Inactive ingredients: zeolite, PEG-8, butylene glycol, ethoxydiglycol, cellulose, sodium lauroyl lactylate, polyethylene, cetearyl alcohol, ceteth-20 phosphate, dicetyl phosphate, cetyl dimethicone, hydroxypropylcellulose, BHT, fragrance, blue 1 lake, yellow 10 lake
The main preservatives in the Biore warming anti blackhead cream cleanser is butylene glycol, which essentially has the same side effects as benzoyl peroxide, but without the acne fighting effects. So your skin will be red, itchy, irritated, sensitive to the sun, peeling, and your acne will not disappear.
All things considered, Biore is a grocery store brand. So you get what you pay for. They make a lot of fancy claims about how it will decimate your blackheads, but nothing to back that claim up. They depend on the idea that you will not actually know anything about blackhead treatments and will therefore buy their product under false assumptions.